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    The Science

    Understand your biomarkers and health scores

    The Precision Diagnostic starts with 100 biomarkers at entry, with up to 125 biomarkers by tier. Our report organizes findings into domain scores for discussion with your clinician. More tests and a score alone cannot establish a diagnosis.

    Last updated: September 24, 2026

    The Panel

    81 Blood Markers + 19 Urinalysis Markers

    The entry set contains 81 blood markers and 19 urinalysis markers. Higher tiers add blood markers, up to 125 biomarkers in total. Confirm which tests your clinician has ordered. The report also considers clinical measurements; routine urinalysis is not comprehensive toxin or hormone-metabolite testing.

    100

    Biomarkers at entry

    81 blood markers and 19 urinalysis markers.

    Up to 125

    Biomarkers by tier

    The ordered set depends on the tier and clinical evaluation.

    60 minutes

    NP interpretation session

    Time to review your findings and questions.

    The Framework

    Seven areas to discuss with your clinician

    Each domain scores 0–100 within our practice-defined reporting framework. These thresholds are not universal diagnostic cutoffs, and a higher score is not proof of better long-term health.

    Metabolic Health

    20% weight

    Key markers: Fasting Glucose, Insulin, HbA1c, HOMA-IR

    Cardiovascular

    20% weight

    Key markers: ApoB, LDL-C, HDL-C, Triglycerides, Lp(a), TC/HDL Ratio

    Inflammation

    15% weight

    Key markers: hs-CRP, Homocysteine, Ferritin, ESR

    Hormonal

    15% weight

    Key markers: Total/Free Testosterone, DHEA-S, Cortisol, Estradiol, SHBG, IGF-1

    Organ Function

    10% weight

    Key markers: ALT, AST, GGT, BUN, Creatinine, eGFR, Albumin

    Blood Health

    10% weight

    Key markers: CBC with differential, Iron, TIBC, Ferritin, B12, Folate

    Body Composition

    10% weight

    Key markers: Clinical measurements considered alongside lab results

    The Score

    How the 1836 Functional Bio Age estimate works

    The 1836 Functional Bio Age combines seven domain scores and expresses the result relative to chronological age. This proprietary estimate is a discussion tool, not a diagnosis, a lifespan prediction or evidence that aging has been reversed.

    1

    100 Markers Collected

    The entry set contains 81 blood markers and 19 urine markers. Your clinician reviews the findings alongside symptoms, history and any relevant clinical measurements.

    2

    Practice-Defined Composite Scores (0–100)

    Findings organized across health areas feed seven composite scores. The weights and score bands describe our reporting approach; they are not independently validated diagnostic thresholds. Laboratory reference ranges and clinical judgment remain part of interpretation.

    3

    Composite → Biological Age

    The weighted composite is compared with a 75-point midpoint. Each point above or below it shifts the estimate by half a year, capped at 15 years in either direction. A change in this calculated value does not demonstrate longer life, reduced mortality or reversal of biological aging.

    Founder's Actual Results: March 2026

    48.3

    Functional Bio Age

    52

    Chronological Age

    −3.7 yrs

    vs. Calendar Age

    In this historical founder example, the calculated score changed from 54.0 to 48.3 over eight months, while the metabolic domain score changed from 39/100 to 79/100. This is one person's experience, not a clinical trial or a typical-result claim. It does not prove aging reversal or establish that the program caused the change. Individual results vary.

    See the full data story

    What testing can and cannot tell you

    Routine preventive care varies with your age, history and clinical needs. There is no fixed number of tests in every annual physical, and additional tests are not automatically better. This service does not replace routine screening, primary care or urgent evaluation.

    Reference ranges usually draw on results from healthy reference groups and vary by laboratory and method. A result within range does not rule out every condition; an out-of-range result does not by itself establish a diagnosis. Read MedlinePlus: understanding lab results for background.

    Our domain scores and Functional Bio Age are practice-defined summaries. They are not validated diagnoses, predictors of lifespan or proof of age reversal or treatment benefit. Changes should be discussed alongside symptoms, medicines, collection conditions and the underlying results.

    For practical next steps, see what the Precision Diagnostic includes and blood-draw preparation and planning. Your clinician decides whether follow-up testing or treatment is appropriate. No prescription or outcome is guaranteed.

    From Data to Action

    Findings to discuss. Next steps to decide.

    Your clinician considers the findings alongside your symptoms, history and priorities, then discusses whether follow-up or treatment is appropriate.

    Review Executive Reset →

    Discuss what your findings mean

    100 biomarkers at entry. Clinician interpretation. A conversation about appropriate next steps.

    Mobile blood draw at your home, office, or hotel

    Further reading: why normal labs can still feel terrible, and the rest of the 1836 Dispatch.